SuppVersity - Nutrition and Exercise Science for Everyone: Maintain & Increase Your Insulin Sensitivity - Wra...

SuppVersity - Nutrition and Exercise Science for Everyone: Maintain & Increase Your Insulin Sensitivity - Wra...: It's not about exercise or nutrition, it's about both of them. And as long as it is not about the former it should not be about su...

• The insulin resistant obese / overweight individual will
  have to target weight and fat loss and increases in insulin resistance; a
  stack that could facilitate all three would contain.
• ALA (or metformin) - 3x 300-500mg 
• Berberine - 3x 200-400mg
• Fucoxanthin - 3x 5mg
• Taurine - 3x 2-3g
• Chromium - 1x 200mcg (*)
• The normal-weight insulin resistant individual will have to take care of inflammation, (usually) a beginning fatty liver and not taking the next step to the obese diabetic.
• Berberine - 3x 200-400mg 
• Chlorogenic acid - 3x 200-300mg
• Taurine - 3x 2-3g
• Milk thistle - 3x 200-400mg
• The cheater can be either of the former or a healthy
  perfectly insulin sensitive individual who wants to reduce the sudden
  rise in blood glucose after a meal.
• Cinnamon - 1-6g (Ceylon cinnamon)
• Vinegar - 2x tablespoons
• Green tea - 1-2 cups

The insulin resistant obese / overweight individual needs relieve
most urgently, therefore he will also trial fucoxanthin, which has some
impressive, but not exactly reliable weight loss data. He will either
have a script for metformin or will use alpha lipoic acid (ALA) as a
substitute and he will make sure that he gets adequate chromium by
taking 200mcg of chromium picoliante or niacin-bound chromium per day *if this is not already in a multi he or she is taking.



The normal-weight insulin resistant individual has slightly
different needs than his overweight comrade. He or she is almost
certainly suffering from chronic inflammation and beginning or existing
NAFLD (the obese will have that, as well, but for him it's only part of
the problem). With it's effects on both AMPK and PPAR-gamma berberine
will make sure that the body fat levels remain low. Just like taurine (read more), chlorogenic acid (Panchal. 2012) and milk thistle (read more), it will also help "revive" the liver and sooth the inflammation by promoting the bodies own antioxidant defense system.



The cheater, on the other hand, could be everyone who wants to
undo (or fore-do, if you will) a high GI carb meal. The ingredients of
this stack will ameliorate the blood sugar response and could thus potentially
reduce any damage you could do to your pancreas... but let's be honest.
With the occasional cheat you are not going to do any damage and if
cheating becomes common practice you violate the "lifestyle-changes
first!" principle and won't get away healthily no matter how much
supplements you take.



 References:

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  prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic
  fatty liver disease in mice by altering expression of hepatic genes
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• Huang TH, Teoh AW, Lin BL, Lin DS, Roufogalis B. The role of herbal
  PPAR modulators in the treatment of cardiometabolic syndrome. Pharmacol
  Res. 2009 Sep;60(3):195-206.
• Moini H, Tirosh O, Park YC, Cho KJ, Packer L. R-alpha-lipoic acid
  action on cell redox status, the insulin receptor, and glucose uptake in
  3T3-L1 adipocytes. Arch Biochem Biophys. 2002 Jan 15;397(2):384-91.
• Neschen S, Morino K, Rossbacher JC, Pongratz RL, Cline GW, Sono S,
  Gillum M, Shulman GI. Fish oil regulates adiponectin secretion by a
  peroxisome proliferator-activated receptor-gamma-dependent mechanism in
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• Panchal SK, Poudyal H, Waanders J, Brown L. Coffee extract
  attenuates changes in cardiovascular and hepatic structure and function
  without decreasing obesity in high-carbohydrate, high-fat diet-fed male
  rats. J Nutr. 2012 Apr;142(4):690-7.
• Toomey S, Harhen B, Roche HM, Fitzgerald D, Belton O. Profound
  resolution of early atherosclerosis with conjugated linoleic acid.
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