Bottom Line: Despite the fact that I have no doubt that the aggravating
effects of high(er) carbohydrate intakes on the metabolic damage due to high fat
dieting is relevant to human beings, as well, it remains to be seen, if these
will occur at the same relatively low amounts of carbohydrate intakes in humans,
as they did in the mice in the study at hand (I assume esp. athletes can
tolerate more).
If we assume this was the case, many people who are
currently jumping aboard the low carb craze, would be ruining their health
unless they this form of dieting only while being in a caloric deficit - a state
that precludes the accumulation of ectopic (visceral) and liver fat and benefits
from an increase in insulin resistance and gluconeogenesis, since both processes
contribute to higher and more stable blood sugar levels - and yes, this is what
we call physiological insulin resistance!
- Mei, Shuang, et al. "A Small Amount of Dietary Carbohydrate Can Promote the
HFD-Induced Insulin Resistance to a Maximal Level." PloS one 9.7 (2014):
e100875.
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