SuppVersity - Nutrition and Exercise Science for Everyone: High Dose 3,5-Diiodo-L-Thyronine (T2) Has Similar ...: No, the rodents had "only" enlarged hearts, but hairloss is a common side effect of elevated thyroid hormones and could theoreti...
Bottom line: As the scientists point
out in their previously cited conclusion, the study at hand clearly
"raise[s] concern about indiscriminate administration of 3,5-T2 as
powerful natural hormone for the treatment of hyperlipidemia and
pandemic obesity" (Jonas. 2014).
This does not mean that you cannot use T2 as a weight loss tool, but in
fact of the previously mentioned absence of human data that would
indicate that it does even work and considering the fact that the study
at hand clearly indicates that it has similar same side effects as T3
(shut down of natural thyroid hormone production, increased heart weight
indicative of myocardial stress) you could just as well use "real"
thyroid hormones instead of 3,5-Diiodo-L-Thyronine (T2) if you are
willing to live with the risk of side effects... or do you disagree?
What are your thoughts and experiences? Let us know on the
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References:
- Antonelli, A., et al. "3, 5-diiodo-L-thyronine increases resting
metabolic rate and reduces body weight without undesirable side
effects." Journal of biological regulators and homeostatic agents 25.4
(2010): 655-660.
- Jonas, Wenke, et al. "3, 5-Diiodo-L-thyronine (3, 5-T2) exerts
thyromimetic effects on hypothalamus-pituitary-thyroid axis, body
composition, and energy metabolism in male dietinduced obese mice."
Endocrinology (2014).
- Padron AS, Neto RAL, Pantaleão TU, de Souza Dos Santos MC,
Araujo RL, de Andrade BM, da Silva Leandro M, de Castro JPSW,
Ferreira ACF, de Carvalho DP. Administration of 3,5-diiodothyronine
(3,5-T2) causes central hypothyroidism and stimulates thyroid sensitive
tissues. J Endocrinol. 221.3 (2014):415–27
